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PAXIL CR GlaxoSmithKline
Paroxetine HCI
Use:
SSRI. Symptomatic relief of depressive illness: Initially, usually in the morning, a 25 mg single daily dose. Patients unresponsive to a 25 mg dose may benefit from dose increases, in 12.5 mg/day increments, at intervals of at least 1 week, to a maximum of 62.5 mg/day. Symptomatic relief of panic disorder: Initially, usually in the morning, a 12.5 mg single daily dose. Dose changes at intervals of at least 1 week should occur in 12.5 mg/day increments. Maximum dosage: 75 mg/day. Social phobia (social anxiety disorder): Initially, usually in the morning, a 12.5 mg single daily dose. Patients unresponsive to a 12.5 mg dose may benefit from dose increases, in 12.5 mg/day increments, at intervals of at least 1 week, to a maximum of 37.5 mg/day. Tablets should be swallowed whole and not chewed or crushed.
Contraindications:
Not to be used with an MAOI or within 14 days of starting or discontinuing MAOI therapy. Concomitant administration of thioridazine. Contraindicated in patients < 18 years of age due to possible increased risk of suicide-related events in this patient populations.
Precautions:
Not recommended for use during pregnancy, in nursing mothers. Epileptic patients, glaucoma, neuroleptic malignant syndrome, renal or hepatic impairment, activation of mania/hypomania, suicidal tendency, MI or unstable heart disease. Efficacy/safety of combined Paxil and electroconvulsive therapy has not been studied. Hyponatremia (reversible), abnormal bleeding. If a decision is made to stop Paxil therapy, the drug should be gradually withdrawn, as abrupt discontinuation may cause withdrawal symptoms.
Side effects:
Nausea, somnolence, sweating, tremor, insomnia, asthenia, dry mouth, dizziness, male sexual dysfunction, constipation, diarrhea, decreased appetite.
Interactions:
See Contraindications. MAOIs, Phenobarbital, theophylline, 5HT1 agonists (e.g., sumatriptan), phenytoin, lithium, anticoagulants (increased bleeding), procyclidine, cimetidine, St. John’s Wort, drugs highly bound to plasma protein, drugs affecting liver enzymes. Avoid concurrent use of paroxetine and tryptophan.
Supplied:
12.5 mg and 25 mg controlled-release tablets.
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